In recent years, drugs used as feed additives have played a role in disease prevention, treatment and growth promotion in animal breeding. If chemical synthetic drugs are abused in feed, it will have a serious negative impact on the healthy development of the feed industry and aquaculture industry and the safety of livestock and poultry products. Taking the most widely used antibiotics as an example, long-term feeding of animals with a sub-therapeutic dose of the animal will increase the number of resistant bacteria in the animal, destroying the immune function of the animal's body, resulting in a decrease in antigen quality. Therefore, our experts have developed a number of new feed additives that enhance animal disease resistance mechanisms, such as probiotics, oligosaccharides, antimicrobial peptides, polyunsaturated fatty acids, and Chinese herbal medicines. First, probiotics The mechanism of action of probiotics is mainly to introduce live bacteria beneficial to animals to the digestive tract, competitively inhibit the pathogens, enhance the immunity of the animal body, and directly participate in the balance of gastrointestinal microbes to maintain normalization of gastrointestinal function. To help the animal establish a gut microflora that is beneficial to the host, and achieve the purpose of preventing disease and promoting growth. Probiotics can effectively increase the activity of interferon and macrophages, promote the production of antibodies by B cells, and the peptidoglycans present on the cell wall can stimulate intestinal immune cells, increase local immune antibodies, and enhance the immune function of livestock and poultry. However, as a live bacterial preparation, probiotics still have many disadvantages that are difficult to overcome. Second, oligosaccharide Functional oligosaccharides such as mannooligosaccharides, fructooligosaccharides, and xylooligosaccharides have health-care functions and growth-promoting effects such as regulating intestinal flora balance and improving immunity. They cannot be digested and absorbed by animals themselves, but they can prevent the pathogens from attaching to the intestines, thereby blocking the path of infection of the bacteria and carrying the pathogens out of the body. Oligosaccharides have good properties in terms of moisture retention, acid resistance, heat resistance and crystallization prevention, and overcome the unstable activity of live bacterial preparations and the difficulty of colonization in the intestinal tract, and do not produce harmful residues of antibiotics. And the problem of drug resistance of pathogens has a broad application prospect. However, the production cost of oligosaccharides is relatively high, and the problems of oligosaccharides and their dosage sizes and addition methods for different animals are still being further studied. Third, antibacterial peptide Antibacterial peptide is a kind of peptide substance induced in vivo. It can resist bacteria, fungi and viruses, and even broad-spectrum activity of protozoa and tumor. It is an important component of animal innate immune system and is widely distributed in various tissues and mucosa of animals. Layer, involved in the body's non-specific immune response. The antibacterial mechanism of antibacterial peptides is a matrix acting on membrane lipids, which increases the permeability of the membrane by physicochemical mechanisms and destroys its barrier to achieve the effect of killing cells. In recent years, antibacterial peptides have become one of the hotspots in the research of antibiotic substitutes, especially lactoferrin peptide, which is considered to be a healthy and safe product. However, there are still some problems in the production of lactoferrin peptide, which restricts its application. Fourth, polyunsaturated fatty acid Polyunsaturated fatty acid (PUFA) refers to a linear fatty acid containing two or more double bonds and having a carbon chain length of 18 to 22 carbon atoms, which can be classified into omega-3 and omega-6 polyunsaturated fatty acids. It is the main body and core of research and development of functional fatty acids. Mainly include α-linolenic acid, linoleic acid, γ-linolenic acid (GLA), arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), etc. It plays an extremely important role in the body. Among them, omega-3 and omega-6 polyunsaturated fatty acids regulate the immune function of animals by affecting lymphocyte proliferation, cytokine synthesis and secretion, and antibody synthesis. Five, Chinese herbal medicine Chinese medicine contains alkaloids, flavonoids, polysaccharides, terpenoids, volatile oils, and some bioactive substances such as polyunsaturated fatty acids, which can directly sterilize and inhibit bacteria, and regulate body metabolism through a large number of physiologically active substances. Enhance immune function. For example, alkaloids can enhance the immune function of body fluids and cells, and stimulate the phagocytic function of macrophages; flavonoids can improve the body's disease resistance by immunomodulating macrophages, lymphocytes and natural killer cells. Studies have shown that some Chinese herbal medicines have achieved good results in controlling livestock diseases. Therefore, some Chinese herbal extract feed additives will replace antibiotics and chemical synthetic drugs, and become an important substance to improve the immune function of animals.
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