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2. Market application
3. Quality indicators
4. Physicochemical properties
5. Storage and transportation
6. Use
1. Basic information
Chinese name: methyl fluoroacetate
Chinese alias: methyl fluoroacetate
English name: Methyl fluoroacetate
English alias: FLUOROACETIC ACID METHYL ESTER; Acetic acid, fluoro-, methyl ester; Aceticacid, fluoro-, methylester; Fluoracetic acid methyl ester; fluoro-aceticacimethylester; Methylester kyseliny fluoroctove; methylesterkyselinyfluoroctove; TL 551; tl551; Methyl fluoroacetate 99%; ethanoic Acid,fluoro-,methyl ester; METHYLESTEROFETODOLAC; CHEM-2063
Formula: C3H5FO2
Structure simple: CH2FCOOCH3
Molecular Weight: 92.07
CAS No.: 453-18-9
EINECS number: 207-218-7
Methyl fluoroacetate is an important fluorine-containing compound and has a wide range of uses and development prospects in the industrial fields of dyes, medicines, and pesticides. In the pharmaceutical industry, fluoroacetate is an important pharmaceutical intermediate, and is the starting material for the preparation of fluoropyrimidine antitumor drugs and fluoroquinoic acid antibacterial drugs, with moderate toxicity.
Fluoropyrimidine antimetabolites are the most commonly used class of antitumor drugs in the clinic. It is effective for solid tumors of epithelial tissues, such as adenocarcinoma, and is equivalent to alkylating agents, antitumor antibiotics and other anti-metabolite anti-tumor drugs, which can be administered orally, intravenously and intra-articularly or intravitally, externally and rectally. The varieties that have been on the market since 1989 are: 5-fluorouracil (5-FU), fluoroglucoside (FUdr), fluoropyridinium (FT-207), diflulorium (FD-1), and carbamoylfluorouracil (HCFU). ), 5-deoxyuridine (5-DFUR), and the like.
Fluoroquinolone acid antibacterial drugs, such as fluridinic acid, ciprofloxacin, bifidoic acid, polyfluridinic acid, sulfinoxacin, etc., are the latest antibacterial drugs that have emerged in the past decade, and their antibacterial spectrum is wide and extensive. Application and treatment of respiratory diseases, digestive tract, urinary tract, soft tissue, skin, lung and other infectious diseases, simple structure, no allergicity of penicillin drugs, lower than the efficacy of antibiotics.
In the first decade of the 21st century, many units in China invested a lot of manpower and material resources to conduct extensive and in-depth research on these two drugs. Among them, many drugs have already achieved large-scale industrial production, and some drugs have passed clinical trials and are being organized. . For this reason, the demand for fluoroacetate will increase greatly in recent years. By the end of the last century, domestic production of ethyl fluoride-free ethyl acetate was only pilot production of fluoroacetic acid methyl ester. Its product index was: 100 ° C ~ 108 ° C volume distillation rate ≥ 85%, total ester content ≥ 98%.
Appearance: colorless transparent liquid
Purity: Industrial grade ≥99%
Package: 100 kg / barrel
Appearance traits, colorless, transparent liquid
Boiling point 104.5 ° C
Relative density 1.1744
Flash point -32 ° C
Vapor pressure (20 ° C) is 80Pa
The refractive index is 1.3679.
The barrel is sealed and stored in a cool place.
[Use 1] used as medicine, pesticide, dye intermediate
[Use 2] Methyl fluoroacetate is the basic raw material for the production of fluazilic acid, ciprofloxacin, 5-fluorouracil, fluoroglucoside, fluoropyridinium, bisfuridine 5-fluoro-4-hydroxypyrimidine, etc. , perfume intermediates.
[Use 3] Methyl fluoroacetate is the basic raw material for the production of fluazilic acid, ciprofloxacin, 5-fluorouracil, fluoroglucoside, fluridine, difuridine, 5-fluoro-4-hydroxypyrimidine and the like.